Blue Flower

CORDIMMUNE(Cordycepin 0.2%)

cordimmune_200
Common price: CAD67.00 Our price: CAD67.00 each

+

Description: CORDIMMUNE contains Cordycepin (0.2%), Adenosine (0.3%) Polysaccharides (18%), the highest contents in the market.

 

The differents between our high quality product and other product?

 

Each capules contains 300mg high concentrated Cordyceps.

 

Resutlts of Analysis:

 

Polysacchardes 26.3%

 

Nitrogen 5.74%

 

Adenosine 0.32%

 

Cordycepin 0.24%

 

Mannitol 3.2%

 

tested by JR Laboratories Inc, 12-3871 North Fraser Way, Burnaby BC, Canada, May 22, 2003

 

Cordyceps, the unique Asian Caterpillar Fungus healing product which now is available to the Western World:

 

What is it?

 

Once so precious and rare, this health restoring tonic made from Cordyceps, a fungus found only at high altitudes in China and Tibet, was available only to Emperors. Today, folklore and science have merged, making this health-restoring agent available to everyone. Our own product which offers this health booster is Cordyceps Sinsensis.

 

Cordyceps gained instant world-wide attention when the international press reported on astonishing new world records set by Chinese women athletes in the 1993 Chinese National Games in Beijing. The reports drew some sceptism at first. Some readers openly wondered if illicit drug use was responsible for the achievements! However, investigation, together with the corroboration of the Chinese Coach, proved the athletes had participated in arduous training at high altitudes, running the equivalent of a marathon a day for half of a year! Reports also showed that such a work-out proved too stressful for Western runners who were not used to doing this nor were they used to working in high altitudes. However, the most important key to opening the secret of the women's success was that they had used a natural tonic?

 

This tonic had been consumed safely for hundreds of years by local people who referred to it as Tong-zhong-chang-cao which translates as Winter worm, summer grass. Cordyceps, once so precious that only the wealthy could obtain it, now had garnered instant international attention!

 

There are numerous types of Cordyceps fungi with experts agreeing that the insect is a hibernating caterpillar which is the food source for the fungus. What might seem like a folk tale from earlier days, a caterpillar magically transformed into a fungus, is an actual happening of the fungus literally smothering the hibernating host upon whom it feeds. Traditionally, it was collected by the vigorous indigenous people mostly mountain tribal groups, who were used to climbing at such high elevations.. The American Entomologist, Winter 1994 edition, printed a description of the caterpillar fungus as recorded in an 1892 book asps and Plant Worms produced by an author simply known as Cooke. He quoted a Professor Westwood who had stated that: It is a Chinese larva, from the back of the neck of each of which a slender fungus, twice as long as the body of the insect, had been produced. This insect, when attacked, is esteemed of great efficacy as a drug in China, where, from its very great rarity, it is only used by the Emperor physicians.

 

What is it known to treat? How does it work?

 

Important as an immunomodulator, it has been used to boost the immune system.

Aids the reproductive system.

Recognized for its ability to improve stamina and appetite, as well as being an effective glandular system booster.

Historically known for its benefit in aiding sexual impotence, also in aiding the reproductive system.

Boosts function of the Liver. Used in clinical studies for liver cirrhosis and hepatitis. Historically used as a beneficial liver tonic.

Kidneys: Historically valued in China for its ability to aid and improve kidney Function. Scientific studies notes in value in aiding renal failure and renal disease.

Lungs: Historically used in China to protecting the lungs.

Stamina and Chronic fatigue: As the Chinese athletes can attest, it is known to improve stamina and appetite, as well as being effective for the entire glandular system.

Memory: Has proven ability to help those in ageing.

A good liver tonic, it has been used in clinical studies both for hepatitis and cirrhosis. Reputed to be a effective detoxifier of the liver.

Chronic fatigue: Benefits those suffering from extreme fatigue, lack of energy.

Difficulty in concentrating or experiencing depression.

Heart: Clinical studies show benefits of use in treating the heart for Arrhythmia. In specific studies quoted in Cordyceps, A Tonic Food of Ancient China (Kennedy Jones, Sylvan Press), noted a specific Cordyceps mycelial Powder used since 1984 to treat some Chinese Hospital patients for their treatment of arrhythmia. It also recorded that 84.8% of arrhythmia patients taking part another trial, showed improvement in supraventicular arrhythmia. This was because they require agents which are faster-acting.

The differents between our high quality product and other product?

 

Each capules contains 300mg high concentrated Cordyceps.

 

Resutlts of Analysis:

 

Polysacchardes 26.3%

 

Nitrogen 5.74%

 

Adenosine 0.32%

 

Cordycepin 0.24%

 

Mannitol 3.2%

 

tested by JR Laboratories Inc, 12-3871 North Fraser Way, Burnaby BC, Canada, May 22, 2003

 

Cordyceps Sinensis

 

Introduction:

 

Cordyceps sinensis (Berk) is a unique fungus that has been used for centuries by the Chinese both as a tonic food and as medicine. In Traditional Chinese Medicine cordyceps Id called ~{!0~}Dong Chong Xia Cao,~{!1~} and is considered to be ~{!0~}sweet and warm~{!1~} in nature and to benefit the Lung and Kidney systems. Wild cordyceps mostly grow in high altitude mountain regions of provinces like Qing Hai, Xi Zang, Yn Xan, and Si Chuan in China. It was very hard to come by and affordable only to the rich and the royalties in the past. However, modern biological advances and fermentation technologies have made it possible to cultivate cordyceps mycelia in mass, making it feasible for the general public.

 

In early 1970s, researchers at the Institute of Materia Medica of the Chinese Academy of Medical Sciences had begun cultivating and analyzing various strains of cordyceps. In 1982, they successfully isolated a strain of cordyceps that is chemically and functionally similar to the wild cordyceps, and named it CS-4 (Paecilonyces hepiali). Since then, fermentation products derived from CS-4 strain have been through many clinical studies in China and other countries, and it has been used extensively in the general Chinese population.

 

Chemical composition of cordyceps sinensis

 

Despite the long historical use and modern clinical researches, the pharmacologically active ingredients of cordyceps are still without a consensus. Cordycepin and dordycepic acid were initially identified by Cunningham et al. (1951) and considered as the active components. Scientists later found that cordycepic acid was in fact d-mannitol, and cordycepin was 3~{!/~}-deoxyadenosine; they could not be accounted for all the known physiological effects of cordyceps. Over the years, various studies on the chemical composition of cordyceps have revealed many known substances, but found no new compound with a significant pharmacological acton. It appears that synergism might be the underlying mechanism by which cordyceps affectsits many wonders on the human body.

 

The chemical constituents isolated from Cordyceps sinensis so far include but not limited to the following:

 

1. Proteins, peptides, and all essential aminoacids

 

2. Sugar derivatives (e.g.d-mannitol), oligosaccharides, and polysaccharides.

 

3. Sterols including ergosterols.

 

4. Nucleoside compounds, including adenine, adenosine, uracil, uridine, guanosine, thymidine, and deoxyuridine.

 

5. Fatty acids and other organic acids.

 

6. Bitamins, including B1, B2, B12, E, and K.

 

7. Micronutrients, including K, Nam Cam Mg, Ge, Cu, Mn, Zn, Pi, Se, Al, Si, Ni, Sr, Ti, Cr, Ga, V, and Zr.

 

Potential Applications of Cordyceps Sinensis (CS):

 

A. Hepato-protective: when rats were fed cordyceps water extract at 200mg/kg for 25 days prior to being given colloidal carbon injection, the half-life of the colloidal carbon was significantly shorter compared to the controls. This indicates that Kupffer cells were stimulated in the treatment group. The secretions of IL-1, IFN, and TNF have also been shown to increase in cultured Kupffer cells when they were exposed to cordyceps extract. In human studies, CS mycelial extract seemed to modulate immune dysfunction in patients with post-hepatieis cirrhosis. Improves CD4/CD8 ratio, increases C4 &C3, restores cellular immunity, and down-regulates hyperfunction of humoral immunity. In chronic hepatits B patients, the disappearance rate of HbsAg, HbeAg, and HBc-IgM were all significantly higher in CS extract treated group compared to the controls.

 

B. Hematopoietic: it has been observed that Cordyceps sinensis stimulates platelet hemopoiesis and erythropoiesis. Clinically, CS mycelial extract is often used to treat chemotherapy induced anemia and thrombocytopenia with great results.

 

C. Immunomodulatory: Cordyceps sinensis seems to have a balancing effect on the immune system; both immuno-suppressive and immuno-stimulating effects of CS have been reported in the literature. In murine T lymphocyte subsets, CS increased the CD4/CD8 ratio in peripheral blood, the spleen weight, phagocyte counts, and phagocytic activity. CS also seems to protect T-helper cells from the immuno-suppressive effects of prednisolone acetate and cyclophosphamide. On the other hand, CS was shown to prolong skin allograft survival time in mice and heart allo-graft survival time in rats. Its immune inhibitory effect appears to be similar to those of cyclosporin A and corticosteroid. Cordyceps sinensis may also be a potential adjunctive treatment for autoimmune conditions. CS has been shown to increase the survival time in lupus mice and to inhibit antu-ds DNA antibody production.

 

D. Nephro-Protective: Cordyceps may be one of the best agents we have against drug-induced kidney toxicities and renal insufficiencies. Studies have shown that CX is quite good as a protective agent against aminoglycoside-induced kidney toxicity and acute kidney failure. Researchers speculate that CS might affect its protection by accelerating tubular cells. CS has also been shown to protect the kidney from cyclosporin-induced nephrotoxicity in rats and in kidney-transplanted patients. Even in other types of nephropathics, CS still olds promise to be a potential treatment, like in IgA nephropathy and chronic renal failure.

 

E. Anti-Cancer: besides having a hematopoietic activity in patiens going through chemotherapy, CS has been shown to have direct anti-tumor activities in vitro. Not only do CS polysaccharides have anti-tumor activities, CS extract devoid of polysaccharides still have strong anti-tumor actions against many tumor cells lines. Unlike other natural anti-tumor agent, CS has been shown to inhibit certain metastasis in mice. In humans, there is evidence that CS improves quality of life in patients with advanced cancer.

 

F. Performance Enhancing: cordyceps is best known to have adaptogenic effects in the sports community. CS gained its notoriety as a performance-enhancing agent in 1993 when a group of Chinese women runners admitted to taking CS as part of their training after breakin nine world records. In animal studies, CS has been shown to increase hepatic [ ATP]/[Pi] ratio in mice incrementally over a 3 week period. This may be the fundamental mechanism for CS~{!/~}s effects on the renal, hepatic, cardiovascular, and many other systems in the human body~{!*~}by increasing intracellular ATP production.

 

G. Other Effects: almost all bodily functions can potentially be enhanced by the ingestion of Cordyceps sinensis. Studies have shown that CS may be considered as a treatment for arrhythmia, sexual hypofunction, tinnitus, and more.

 

Toxicity

 

Cordyceps long historical use and modern toxicity rescarches all speak of a very safe fungal product. When mice were given 80g/kg of cultivated CS mycelial extract of wild CS by mouth for 7 days or more, there were no signs of toxicity or death occurred. In the Ames test with strains of Salmonella typhimurium, various strains of cultured CS mycelial extract procuced no mutagenicity. When mycelial extract of the Cs-4 strain was fed to rats at 3g/kg for 3 months, there was also no toxicity or death found in either sexes.

 

Choosing cultivated vs. wild cordyceps sinensis:

 

Countless studies have confirmed the medical value of deep-layer fermented CS mycelisl extract, which is comparable to the wild cordyceps both in chemical composition and in clinical effectiveness. Since the wild cordyceps is so much more expensive, for clinical applications the cultivated CS mycelial extract should be the obvious choice. If the patient insists on taking the wild cordyceps, then the potential for lead poisoning should be carefully assessed. There have been reports of tiny lead bars being inserted into the wild cordyceps in order to increase the weight by unscrupulous merchants. Amongst the various strains of cultivated CS, Cs-4 should be the choice for clinical use because it is the most extensively researched. Next, one should look at the ingredients profile of the particular Cs-4 mycelial extract. Due to the variation in the techniques and expertise of fermenting and extracting the cordyceps mycdlia, there will be differences in the composition of the end products. Good manufacturers would usually test for three marker ingredients, namely polysaccharides, mannitol (or cordycepic acid), and adenosine concentrations. Of the three markers, adenosine percentage is often regarded as the main indicator of quality and is also the most difficult to increase. In order to be considered a good CS mycelial extract, the adenosine level should be at least 0.1%; a better product should be cclose or higher than 0.2%.

 

References

 

1. Yeung HC. Handbook of Chinese Herbs, 2nd Edition. (California, Institute of Chinese Medicine, 1996): 159.

 

2. Halpern GM. Cordyceps: China~{!/~}s Healing Mushroom. (New York, Avery Publishing Group, 1999):13

 

3. Zhu Js, Halpern GM, Jones K. 1998. The scientific discovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part 1. J. Alternative & Complementary Med. 4:289-303

 

4. Sprecher M, Sprinson DB. 1963. A reinvestigation of the structure of cordycepic acid? J. Org. Chem. 28: 2490-91.

 

5. Lu RM, Yang YC, Yang YP, Wang SF. 1981. Study on chemical constituents in Cordyceps sinensis Sacc. Chin. Pharm. Bull: 1655

 

6. Xu WH, Xuc.Z, Ma JM. 1988. Water-soluble constituents in Cordyceps sinensis. 1. Bull. Chin. Mat. Med. 8: 32-33.

 

7. Xiao YQ, Liu JM, Tu YY. 1983. Studied on chemical constituents in Cordyceps sinensis. 1. Bull. Chin. Mat. Med: 32-33

 

8. Nakamura K, Yamaguchi Y, Kagota S, et al. 1999. Activation of in vivo kupffer cell function by oral administration of Cordyceps sinensis in rats, Jpn. J. Pharmacol. 79: 505-508.

 

9. Liu P, Zhu J, Huang Y, Liu C, 1996. Influence of Cordyceps sinensis(Berk.) Sacc. And rat serum containing same medicine on IL-1, IFN and TNF produced by rat kupffer. China J. Chin. Materia Medica. 21: 367-69.

 

10. Zhu JL, Liu C.1992. Modulating effects of extractum semen Persicae and cultivated Cordyceps hyphae on immuno-dysfunction of in-patints with post-hepatitis cirrhosis. Chung-Kuo Chung his 1 Chieh Ho Tsa Chih. 12: 207-09.

 

11. He JJ, Zhu D, Huang LL, 1992. using Codyceps sinensis to treat chronic hepatitis B. Journal of Zhejiang college of TCM. 16(1): 12-13.

 

12. Chen DM. 1987. Platelet hemopoiesis and ultrastructure observations in mice treated with natural Cordyceps sinensis and its cultured mycelia. Bull. Chin. Materia Medica. 12: 47-49.

 

13. Li Y, Chen GZ, Jiang DZ. 1993. Effect of Cordyceps sinensis on erythropoiesis in mouse bone marrow. Chin. Med. J. 106: 313-16.

 

14. Chen GZ, Chen GL, Sun T, Hsieh GC, Henshall JM. 1991. Effects of Cordyceps sinensis on murine T lymphocytes subsets. Chin. Med. J. 104: 4-8.

 

15. Zhu XY, Yu HY. 1990. Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response. Chin. J. Modern Developments Traditional Med. 10: 485-87.

 

16. Zhang Z, Xia SS. 1990. Cordyceps sinensis-1 as an immunosuppressant in heterotopic allograft model in rats. J. Tongji Med. Univ. 10: 100-103.

 

17. Chen JR, Yen JH, Lin CC, Tsai WJ, Liu WJ, et al. 1993. The effects of Chinese herbs on improving survival and inhibiting anti-ds DNA antibody production in lupus mice. Amer. J. Chin. Med 21: 257-262.

 

18. Li LS, Zheng F, Liu ZH. 1996. Experimental study on effect of Cordyceps sinensis in ameliorating aminoglycoside induced nephrotoxicity. Chung-kuo Chung his 1 Chieh Ho Tsa Chih. 16: 733-737.

 

19. Zhen F, Tian J, Li LS. 1992. Mechanisms and therapeutic effects of Cordyceps sinensis (CS) on aminoglycosice induced acute renal failure (ARF)in rats. Chung-Kuo Chung His 1 Chieh Ho Tsa Chih. 12: 288-291.

 

20. Bao ZD, Wu ZG, Zheng F. 1994. Amelioration of aminoglycosice nephrotoxicity by Cordyceps sinensis in old patients. Chung-Kuo His 1 Chieh Ho Tsa Chih. 14: 271-273.

 

21. Zhao X, Li L 1993. Cordyceps sinensis in protection of the kidney from cyclosporin a nephrotoxicity. Chin. Med. J 73: 410-412.

 

22. Xu F, Huang JB, Jiang L, Xu J, Mi J. 1995. Amelioration of cyclosporin nephrotoxicity by Cordyceps sinensis in kidney-transplanted recipients. Nephrol. Dialysis Transplant 10: 142-43.

 

23. Lin CY, Ku FM, Kuo YC, et al. 1999. Inhibition of activated human mesangial cell proliferation by the natural product of Cordyceps sinensis (H1-A): an implication for treatment of IgA mesangial nephropathy. J. Lab. & Clin. Med. 133: 55-63.

 

24. Chen YP, Liu WZ, Shen LM, Xu SN. 1986. Comparison of natural and cultured Cordyceps sinensis in the treatment of 30 chronic renal failure patients. Chinese Herbal Medicine. 17(6): 16-18.

 

25. Guan YJ, Hu Z, Hou M, et al. 1992. Effects of Cordyceps sinensis on chronic renal failure and cell subgroups. Chinese Journal of Western and Chinese Medicine Cooperation. 12(6): 338-339.

 

26. Yoshida J, Takamura S, Yamaguchi N, et al. 1989. Antitumor activity of an extract of Cordyceps sinensis (Berk.) Sacc. Against murine tomor cell lines. Jpn. J. Exp. Med. 15: 157-161.

 

27. Kuo YC, Lin CY, Tsai WJ, et al. 1994. Growth inhibitors. Against tumor cells in Cordyceps sinensis other than cordycepin and polysaccharides. Cancer Invest. 12: 611-615.

 

28. Nakamura K, Yamaguchi Y, et al. 1999. Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung cafcinoma and B16 melanoma cells in syngeneic mice. Jpn. J. Pharmacol 79: 335-341.

 

29. Zhao DH, Lin LZ. 1995. Effect of Jinshuibao capsule on the immunological function of 36 patients with advanced cancer. Chung-Kuo Chung Jis 1 Chueh Ho Tsa Chih. 15: 476-78.

 

30. Manabe N, Sugioto M, et al. 1996. Effects of the mycelisl extract of cultured cordyceps sinensis on in vivo hepatic energy metabolism in the mouse. Jpn. J. Phamacol. 70: 85-88.

 

31. Yu Hs. 1985. Treatment of arrhythmia with Cordyceps sinensis. J Zhejiang Trad. Chin. Med. Coll. 9: 28.

 

32. Yang WZ, Deng Xa, Hu W. 1985. Treatment of sexual hypofunction with Cordyceps sinensis. Jiangxi Zhongyiyao. 5: 46-47.

 

33. Zhuang JM, Chen HL. 1985. Treatment of tinnitus with Cordyceps infusion: a report of 23 cases. Fujian Med. J 7: 42.

 

34. Zhu JS, Halpern GM, Jones K. 1998a. The scientific discovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part 1. J Alternative & Complementary Med. 4: 429-457.

 

35. Jing AH, Tao QP, Zhang YG. 1987. Studies on teratogenicity of mycelial powder of Cephalosporium sinensis of Cordyceps. Trad. Chin. Mat. Med. 18: 45

 

36. Xu F. 1992. Pharmaceutical studies of submerged culture of /cordyceps mycelia in China. Chin. Phamaceutical J. 27: 195-197.

 

37. Huang YM, Lu JB, Zhu BC, et al. 1987. Toxicity study of Cordyceps mycelial fermentation B414. jZhongchengyao. 10: 24-25.

 

38. Wu TN, Yang KC, Wang CM et al. 1996. Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports. The Science of the Total Environment. 192: 193-195.

 

 

 

Beneficial: Appetite loss, Arrhythmia, Aging, Anxiety, Cancer, Chronic Fatigue, Chemotherapy support, Energy, Fatigue, Glandular system, Heart, Hepatitis, Immune system, Kidneys, Liver, Liver cirrhosis, Detoxifier, Lungs, Heart, Reproductive system, Radiotherapy, Sexual Impotence, Stamina, Hair loss, sleeping problems,Blood circulation.

 

Quantity Per Unit: 60 Caps 300mg

 

 

 

Manufacturer: DNA Canada